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Research In Our Department

In our department, Biomedical Photonics researches continue on the including " Development of Photodynamic Therapy (PDT) Laser Systems, Photodynamic Diagnostic (PDD) Systems and Medical Instrumentation and Tissue Optics.

PHOTODYNAMIC THERAPY (PDT)

* Principle of Photodynamic Therapy

Photodynamic Therapy(also known as PDT) is a minimally invasive treatment method for use in wide range of disease characterized by hyperproliferating cells. Using a photosensitizing drug(which is selectively absorbed by neoplastic or cancerous tissue) and a non-thermal laser light with a specific wavelength, PDT can selectively destroy targeted tissues through the subsequent radical reactions caused by singlet oxygen which is generated from the molecular oxygen in the mitochondria of tumor cell. In addition, PDT may be used to treat non-obstructive cancer in patients who are not desire a surgical approach.

-PDT-induced target tissue destruction requires the presence of oxygen and is thought to be due to the production of singlet oxygen for direct cytotoxic effect; a microvascular shutdown effect is also observed that results in tumor death from oxygen starvation(ischemic necrosis). Vascular endothelium may selectively take up photosensitizer within tumor tissue.

- Singlet oxygen generated by a photochemical reaction between a photosensitizer and a non-thermal laser light can form superoxide and hydroxy radical, and the subsequent radical reactions begin to destroy tumor cells without affecting healthy cells. Tumor death also occurs through is chematic necrosis secondary to vascular occlusion that appears to be partly mediated by thromboxane A2 release.

- The diseased cells die; their remains are broken down by metabolic processes.
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* Photodynamic Therapy (PDT) Laser Systems

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Photodynamic Diagnosis(PDD)                   Tissue Optics